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Lucas Antônio Duarte Nicolau

Universidade Federal do Delta do Parnaíba · PI · 37 publicações em 2022–2026

docente de pós-graduaçãoORCID 0000-0002-9904-2168

Polysaccharides Composition and ApplicationsGastroesophageal reflux and treatmentsGastrointestinal motility and disordersInflammatory mediators and NSAID effectsCOVID-19 Clinical Research Studies

Programas de pós-graduação (CAPES)

5BiotecnologiaUFDPAR · docente permanente (2024)4FarmacologiaUFPI · docente permanente (2024)

Principais coautores no Nordeste tamanho = publicações em comum

Jand Venes Rolim Medeiros Marcellus Henrique Loiola Ponte de Souza Gabriella Pacheco André Luís Fernandes Lopes Antonio Carlos Pereira de Oliveira Durcilene Alves da Silva Katriane Carvalho da Silva Thiago M. Sales Humberto Barbosa da Costa Filho Jefferson Almeida Rocha Pedro Marcos Gomes Soares Álvaro Xavier Franco

Orientações concluídas (CAPES)

SÍNTESE E CARACTERIZAÇÃO DA GOMA DO CAJUEIRO (ANACARDIUM OCCIDENTALE L.) TIOLADA: POTENCIAL USO NA DOENÇA DO REFLUXO GASTROESOFÁGICO
dissertação · GABRIELLE COSTA SOUSA · BIOTECNOLOGIA · 2024
EFEITO ESOFAGOPROTETOR DA GOMA DE CITRUS × LATIFOLIA NA ESOFAGITE EROSIVA EM RATOS
dissertação · LUIZ FERNANDO LOPES SOARES TEIXEIRA · BIOTECNOLOGIA · 2023

Publicações recentes

2026 7

The protease inhibitor darunavir prevents esophagitis and impairments in esophageal barrier function in a mouse model of GERD
Medicina · American Journal of Physiology-Gastrointestinal and Liver Physiology
Gastro-oesophageal reflux disease as a disorder of immune dysregulation driven by microbial deprivation: Extending the hygiene hypothesis to the oesophagus
Medicina · Medical Hypotheses
Farnesoid X receptor blockade attenuates morphological damage, intestinal secretion, and prevents mucus loss induced by SARS-CoV-2 spike protein in the mouse intestine
Medicina · Journal of Pharmacy and Pharmacology
Bionutri AR1® as a fermentation-derived multicomponent food matrix: Glucan structure, extracellular immune responses, and current mechanistic gaps
Ciências agrárias e biológicas · Journal of Functional Foods
Editorial: Community series in reducing adverse effects of cancer immunotherapy, volume III
Medicina · Frontiers in Immunology
Targeting pepsin provides superior protection to acid suppression in reflux‐associated airway inflammation and lung dysfunction
Medicina · Experimental Physiology
Alpha-ketoglutarate supplementation ameliorates castor oil-induced diarrhea in mice: in silico and in vivo insights
Medicina · Brazilian Journal of Medical and Biological Research

2025 5

Cashew gum fractions protect intestinal mucosa against shiga toxin-producing Escherichia coli infection: Characterization and insights into microbiota modulation
Ciências agrárias e biológicas · International Journal of Biological Macromolecules
Lemon gum blankets esophageal mucosa and promotes therapeutic effects in experimental models of gastroesophageal reflux disease: Grasps for prevention and treatment
Ciências agrárias e biológicas · Carbohydrate Polymers
Topical effect of polysaccharide cashew gum on the mitigation of dentin erosion progression under in vitro supraesophageal reflux simulation
Odontologia · Archives of Oral Biology
Mucosal integrity of the larynx and hypopharynx and the response to proton pump inhibitors in patients with laryngopharyngeal reflux
Medicina · European Archives of Oto-Rhino-Laryngology
Cajuína from Piauí (Brazil): implications of a cultural beverage with nutraceutical potential in the management of peptic oesophagitis
Ciências agrárias e biológicas · International Journal of Food Science & Technology

2024 14

Pepsin Inhibitors Prevent Inflammation and Loss of Laryngeal Barrier Function in Mice with Gastroesophageal Reflux
Medicina · The Laryngoscope
SARS-CoV-2 Spike protein triggers gut impairment since mucosal barrier to innermost layers: From basic science to clinical relevance
Medicina · Mucosal Immunology
Gastroprotective activity and physicochemical analysis of carboxymethylated gum from Anadenanthera colubrina
Ciências agrárias e biológicas · International Journal of Biological Macromolecules
Long-term administration of omeprazole in mice: a study of behavior, inflammatory, and oxidative stress alterations with focus on central nervous system
Neurociência · Naunyn-Schmiedeberg s Archives of Pharmacology
Cardiotoxic Effects Produced by Omeprazole and Methylene Blue in an Animal Model of Cardiac Ischemia and Reperfusion and Potential Implications for the Pharmacological Strategy for Vasoplegic Syndrome
Medicina · Biomedicines
Inquiring into the collusion between two-system diseases: Potential impact of hypertension over gastroesophageal reflux disease
Medicina · Medical Hypotheses
Cardiotoxic and Cardioprotective Effects of Methylene Blue in the Animal Model of Cardiac Ischemia and Reperfusion
Medicina · Biomedicines
Comprehensive analysis of gastrointestinal side effects in COVID-19 patients undergoing combined pharmacological treatment with azithromycin and hydroxychloroquine: a systematic review and network meta-analysis
Medicina · Critical Reviews in Toxicology
Diminazene Aceturate Inhibits the Sars-Cov-2 Spike Protein-Induced Inflammation Involving Leukocyte Migration and DNA Extracellular Traps Formation
Imunologia e microbiologia · Life Sciences
Potential Clinical Benefits And Probable Mechanisms of Action Promoted By A Nutraceutical Obtained By Fermentation And Rich In Β-Glucans And Amino Acids for Oncologic Patients
Enfermagem · Journal of Medical Residency Review
Potential Uses of Polysaccharides from Plant Exudates for Treating Gastrointestinal Diseases
Ciências agrárias e biológicas · Revista Brasileira de Farmacognosia
Pharmacological therapy with azithromycin, hydroxychloroquine and ivermectin increased gastrointestinal side effects in a population in northeast Brazil
Medicina · Peer Review
Exploring the clinical relevance of “Angico Gum”: an effective biopolymer for topical protection of oesophageal mucosa in gastroesophageal reflux disease patients
Medicina · Journal of Pharmacy and Pharmacology
Use of etomidate in endotracheal intubations in the emergency room during the COVID-19 pandemic: a randomized clinical trial
Medicina · Acta Cirúrgica Brasileira

2023 4

Pharmacological Modulation of the Ca2+/cAMP/Adenosine Signaling in Cardiac Cells as a New Cardioprotective Strategy to Reduce Severe Arrhythmias in Myocardial Infarction
Medicina · Pharmaceuticals
Protective effect of alpha-ketoglutarate against water-immersion restraint stress-induced gastric mucosal damage in mice
Medicina · European Journal of Pharmacology
Pharmacological Modulation by Low Molecular Weight Heparin of Purinergic Signaling in Cardiac Cells Prevents Arrhythmia and Lethality Induced by Myocardial Infarction
Bioquímica, genética e biologia molecular · Journal of Cardiovascular Development and Disease
Role of cyclooxygenases 1 and 2 in the maintenance of colonic mucosal integrity in an experimental colitis model
Medicina · Brazilian Journal of Medical and Biological Research

2022 7

Dietary polysaccharides from guavira pomace, a co-product from the fruit pulp industry, display therapeutic application in gut disorders
Medicina · Food Research International
Laryngeal and Esophageal Mucosal Protection Using the Angico Gum Biopolymer in a Mouse Model of Reflux
Medicina · The Laryngoscope
Antiviral potential of diminazene aceturate against SARS-CoV-2 proteases using computational and in vitro approaches
Medicina · Chemico-Biological Interactions
BR-bombesin: a novel bombesin-related peptide from the skin secretion of the Chaco tree frog (Boana raniceps) with physiological gastric effects
Neurociência · Amino Acids
Risk of Cardiac Lesion with Chronic and Acute Use of Loperamide—An Integrative Review
Medicina · Journal of Cardiovascular Development and Disease
Benefícios promovidos pela utilização de um nutracêutico produzido por fermentação altamente biodisponível, rico em β-glucanas e aminoácidos, para pacientes oncológicos tratados com quimioterapias e radioterapias
Enfermagem · Research Society and Development
Editorial: Gastrointestinal tract barrier damage in health and in inflammatory diseases
Medicina · Frontiers in Physiology

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