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Bruno Solano de Freitas Souza

Instituto Gonçalo Moniz · BA · 41 publicações em 2022–2026

ORCID 0000-0003-3771-0439

Mesenchymal stem cell researchTrypanosoma species research and implicationsCardiac Fibrosis and RemodelingPluripotent Stem Cells ResearchCOVID-19 Clinical Research Studies

Principais coautores no Nordeste tamanho = publicações em comum

Carolina Kymie Vasques Nonaka Clarissa Araújo Gurgel Rocha Erik Aranha Rossi Sílvia Lima Costa Erick Correia Loiola Zaquer Suzana Munhoz Costa‐Ferro Kátia Nunes da Silva Maria de Fátima Dias Costa Ana Verena Almeida Mendes Gisele Vieira Rocha Milena Botelho Pereira Soares Rachel Santana Cunha

Publicações recentes

2026 4

From cellular toxicity and inflammation to human safety: An integrated in vitro–in silico assessment of 5-hydroxymethylfurfural (HMF)
Bioquímica, genética e biologia molecular · Toxicology Letters
The Flavonoid Rutin Enhances Temozolomide Sensitivity in Glioblastoma Spheroids by Modulating Chemoresistance via PI3K/AKT, STAT3, Redox and Kynurenine Pathways, and Altering ECM Remodeling Associated with Reduced Migration
Medicina · Antioxidants
Accelerating Proficiency in Minimally Invasive Autopsy for Infectious Disease Diagnosis and Research: A Strategic Framework
Medicina · Revista da Sociedade Brasileira de Medicina Tropical
Paving the way for translational relevance in advanced therapies in Brazil: conference report from SBINT 2025
Enfermagem · Regenerative Medicine

2025 12

Chondroitinase ABC in spinal cord injury: advances in delivery strategies and therapeutic synergies
Medicina · Frontiers in Bioengineering and Biotechnology
Extracellular vesicles derived from mesenchymal stem cells alleviate depressive-like behavior in a rat model of chronic stress
Bioquímica, genética e biologia molecular · Life Sciences
Extracellular Vesicles as Therapeutic Strategy for Ischemic Stroke
Bioquímica, genética e biologia molecular · Journal of Neurochemistry
Curcumin triggers reactive oxygen species-mediated apoptosis and suppresses tumor growth in metastatic oral squamous cell carcinoma
Bioquímica, genética e biologia molecular · Frontiers in Oncology
Immunomodulatory and regenerative effects of human umbilical cord MSC-EVs in Cutaneous Leishmaniasis
Bioquímica, genética e biologia molecular · Stem Cell Research & Therapy
Dichloromethane Extract from Amburana cearensis (Allemão) A.C. Sm. Seeds and Its Coumarin Reduce ROS Production and Protect PC12 Cells Against Glutamate Excitotoxicity and Oxygen-Glucose Deprivation
Medicina · Antioxidants
Agathisflavone Inhibits Viability and Modulates the Expression of miR-125b, miR-155, IL-6, and Arginase in Glioblastoma Cells and Microglia/Macrophage Activation
Medicina · Molecules
Functional heterogeneity of mesenchymal stem cells and their therapeutic potential in the K18-hACE2 mouse model of SARS-CoV-2 infection
Bioquímica, genética e biologia molecular · Stem Cell Research & Therapy
Exercise training reduces cardiac fibrosis, promoting improvement in arrhythmias and cardiac dysfunction in an experimental model of chronic chagasic cardiomyopathy
Medicina · Frontiers in Physiology
Agathisflavone Modulates the Kynurenine Pathway and Glial Inflammatory Responses with Implications for Neuroprotection
Neurociência · International Journal of Molecular Sciences
Early intervention with extracellular vesicles derived from human umbilical cord mesenchymal stem cells enhances survival and functional recovery after spinal cord injury in rats
Medicina · Frontiers in Pharmacology
Generation and characterization of human-induced pluripotent stem cell lines from patients with autism spectrum disorder and SCN2A variants
Bioquímica, genética e biologia molecular · Human Cell

2024 9

Flavonoid Rutin Presented Anti-Glioblastoma Activity Related to the Modulation of Onco miRNA-125b Expression and STAT3 Signaling and Impact on Microglia Inflammatory Profile
Medicina · Brain Sciences
GMP-compliant extracellular vesicles derived from umbilical cord mesenchymal stromal cells: manufacturing and pre-clinical evaluation in ARDS treatment
Bioquímica, genética e biologia molecular · Cytotherapy
In silico approaches for drug repurposing in oncology: a scoping review
Farmacologia e toxicologia · Frontiers in Pharmacology
Potential of extracellular vesicles in the pathogenesis, diagnosis and therapy for parasitic diseases
Bioquímica, genética e biologia molecular · Journal of Extracellular Vesicles
Genome Editing Therapy for the Blood: Ex Vivo Success and In Vivo Prospects
Bioquímica, genética e biologia molecular · The CRISPR Journal
Transplantation of autologous mesenchymal stromal cells in complete cervical spinal cord injury: a pilot study
Medicina · Frontiers in Medicine
The Phytochemical Agathisflavone Modulates miR146a and miR155 in Activated Microglia Involving STAT3 Signaling
Neurociência · International Journal of Molecular Sciences
Proteomics of serum-derived extracellular vesicles are associated with the severity and different clinical profiles of patients with COVID-19: An exploratory secondary analysis
Bioquímica, genética e biologia molecular · Cytotherapy
Assessing the Clinical Impact of the SARS-CoV-2 Gamma Variant on Intensive Care Unit Admissions: Insights from a Reference Hospital in Northeastern Brazil
Medicina · Viruses

2023 9

Modeling Autism Spectrum Disorders with Induced Pluripotent Stem Cell-Derived Brain Organoids
Bioquímica, genética e biologia molecular · Biomolecules
Standardized Brazilian green propolis extract (EPP-AF®) in COVID-19 outcomes: a randomized double-blind placebo-controlled trial
Ciências agrárias e biológicas · Scientific Reports
Leishmania infection alters macrophage and dendritic cell migration in a three-dimensional environment
Medicina · Frontiers in Cell and Developmental Biology
Cytogenomic Investigation of Syndromic Brazilian Patients with Differences of Sexual Development
Bioquímica, genética e biologia molecular · Diagnostics
Evaluation of 2D and 3D Erythroid Differentiation Protocols Using Sickle Cell Disease and Healthy Donor Induced Pluripotent Stem Cells
Bioquímica, genética e biologia molecular · Cells
Rapid Detection of SARS-CoV-2 Based on the LAMP Assay Associated with the CRISPRCas12a System
Medicina · Diagnostics
Use of Three-Dimensional Cell Culture Models in Drug Assays for Anti-Cancer Agents in Oral Cancer: Protocol for a Scoping Review
Medicina · Journal of Personalized Medicine
SARS-CoV-2 Detection via RT-PCR in Matched Saliva and Nasopharyngeal Samples Reveals High Concordance in Different Commercial Assays
Medicina · Diagnostics
Generation of an induced pluripotent stem cell line from a patient with epileptic encephalopathy caused by the CYFIP2 R87C variant
Bioquímica, genética e biologia molecular · Human Cell

2022 7

Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): a phase 4, non-inferiority, single blind, randomised study
Medicina · The Lancet
MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise
Bioquímica, genética e biologia molecular · Reviews in Cardiovascular Medicine
Cell-in-Cell Events in Oral Squamous Cell Carcinoma
Medicina · Frontiers in Oncology
Agathisflavone as a Single Therapy or in Association With Mesenchymal Stem Cells Improves Tissue Repair in a Spinal Cord Injury Model in Rats
Medicina · Frontiers in Pharmacology
The use of standardized Brazilian green propolis extract (EPP-AF) as an adjunct treatment for hospitalized COVID-19 patients (BeeCovid2): a structured summary of a study protocol for a randomized controlled trial
Ciências agrárias e biológicas · Trials
Arsenic Trioxide Triggers Apoptosis of Metastatic Oral Squamous Cells Carcinoma with Concomitant Downregulation of GLI1 in Hedgehog Signaling
Bioquímica, genética e biologia molecular · Biomedicines
Efficacy and Safety of Granulocyte-Colony Stimulating Factor Therapy in Chagas Cardiomyopathy: A Phase II Double-Blind, Randomized, Placebo-Controlled Clinical Trial
Medicina · Frontiers in Cardiovascular Medicine

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