Sílvia Lima Costa

Universidade Federal da Bahia · BA · 54 publicações em 2022–2026

Flavonoids in Medical ResearchNeuroinflammation and Neurodegeneration MechanismsGlioma Diagnosis and TreatmentParkinson's Disease Mechanisms and TreatmentsPhytochemistry Medicinal Plant Applications

Principais coautores no Nordeste tamanho = publicações em comum

Víctor Diógenes Amaral da Silva Maria de Fátima Dias Costa Cleonice Creusa dos Santos Ravena Pereira do Nascimento Balbino Lino dos Santos Érica Novaes Soares Jorge M. David Bruno Solano de Freitas Souza Fillipe Mendes de Araújo Juciele Valéria Ribeiro de Oliveira Monique Reis de Santana Maurício M. Victor

Publicações recentes

2026 10

Synthesis, Characterization, Antioxidant and Antimicrobial Potentials of Novel Organometallic Compounds Derived from Quercetin
Medicina · Scientia Pharmaceutica
The Flavonoid Rutin Enhances Temozolomide Sensitivity in Glioblastoma Spheroids by Modulating Chemoresistance via PI3K/AKT, STAT3, Redox and Kynurenine Pathways, and Altering ECM Remodeling Associated with Reduced Migration
Medicina · Antioxidants
The Flavonoid Apigenin Modulates Oligodendroglial Plasticity and Has a Neuroprotective Effect in Cerebellar Slice Cultures with Oxygen Glucose Deprivation
Medicina · Nutrients
Flavonoid Rutin Reduces Intestinal Inflammation in an Experimental Model of Parkinson's Disease
Medicina · Neurotoxicity Research
Apigenin as a Potential Modulator of Neuroinflammation in Multiple Sclerosis: A Review
Medicina · Biology
A Primary Spinal Cord Mixed Culture Method for In Vitro Analysis of Glial Heterogeneity and Inflammatory Responses
Neurociência · Neurochemical Research
Neuroprotection Across Cerebellar and Nigrostriatal Degeneration: Translational Insights from Parkinson’s Disease to Spinocerebellar Ataxia Type 2
Neurociência · The Cerebellum
Rutin Attenuates Microglial Inflammatory Responses by Promoting M2-like Polarization via GDNF and SHH/GLI-1 Signaling and NLRP3 Inflammasome Inhibition
Neurociência · Neuroglia
Historical and Current Ethnographic Use of Tobacco in Brazil: Implications for the Medicinal Use of Nicotine in Parkinson's Disease
Medicina · Journal of Environmental Science and Public Health
Correction: A Primary Spinal Cord Mixed Culture Method for In Vitro Analysis of Glial Heterogeneity and Inflammatory Responses
Neurociência · Neurochemical Research

2025 16

Tryptophan Metabolism Through the Kynurenine Pathway in Glial Cells
Neurociência · Neuroglia
New perspectives on heterogeneity in astrocyte reactivity in neuroinflammation
Neurociência · Brain Behavior & Immunity - Health
Naringenin Exhibits Antiglioma Activity Related to Aryl Hydrocarbon Receptor Activity and IL-6, CCL2, and TNF-α Expression
Medicina · Brain Sciences
Agathisflavone Inhibits Viability and Modulates the Expression of miR-125b, miR-155, IL-6, and Arginase in Glioblastoma Cells and Microglia/Macrophage Activation
Medicina · Molecules
Dichloromethane Extract from Amburana cearensis (Allemão) A.C. Sm. Seeds and Its Coumarin Reduce ROS Production and Protect PC12 Cells Against Glutamate Excitotoxicity and Oxygen-Glucose Deprivation
Medicina · Antioxidants
Apigenin Induces Autophagy and Apoptosis in Chemoresistant Glioblastoma Cells and Inhibits Tumorigenicity Associated with Regulation of Immunomodulatory Proteins and Glial Cells Response
Medicina · Cells
Synthesis of Naringenin and Senecioic Acid Ester Derivatives and Biological Evaluation of the Astrocyte Antioxidant Mechanism and Reactivity After Inflammatory Stimulus
Medicina · International Journal of Molecular Sciences
Agathisflavone Modulates the Kynurenine Pathway and Glial Inflammatory Responses with Implications for Neuroprotection
Neurociência · International Journal of Molecular Sciences
ConA-glutamate interactions: New insights into its neuroprotective effect
Bioquímica, genética e biologia molecular · International Journal of Biological Macromolecules
Early intervention with extracellular vesicles derived from human umbilical cord mesenchymal stem cells enhances survival and functional recovery after spinal cord injury in rats
Medicina · Frontiers in Pharmacology
The Biflavonoid Agathisflavone Regulates Microglial and Astrocytic Inflammatory Profiles via Glucocorticoid Receptor
Neurociência · Molecules
The Secretome of Brain Endothelial Cells Exposed to the Pyrrolizidine Alkaloid Monocrotaline Induces Astrocyte Reactivity and Is Neurotoxic
Farmacologia e toxicologia · Toxins
The Flavonoid Agathisflavone Attenuates Glia Activation After Mechanical Injury of Cortical Tissue and Negatively Regulates Both NRLP3 and IL-1β Expression
Medicina · International Journal of Molecular Sciences
JM-20 administration to animals with lesion of the nigrostriatal dopamine pathway induced by 6-hydroxydopamine, partially reverses motor damage and oxidative stress
Medicina · Neurological Research
Striatal injection of aminochrome in Wistar rats induces early-stage behavioral changes of Parkinson's disease and dopaminergic degeneration in the caudal and medial regions of the nigra pars compacta
Medicina · Neurochemistry International
Rosenfeld’s Staining: A Valuable Tool for In Vitro Assessment of Astrocyte and Microglia Morphology
Neurociência · Neuroglia

2024 11

Flavonoid Rutin Presented Anti-Glioblastoma Activity Related to the Modulation of Onco miRNA-125b Expression and STAT3 Signaling and Impact on Microglia Inflammatory Profile
Medicina · Brain Sciences
Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease
Medicina · Cells
Effect of the Flavonoid Rutin on the Modulation of the Myenteric Plexuses in an Experimental Model of Parkinson’s Disease
Medicina · International Journal of Molecular Sciences
The Phytochemical Agathisflavone Modulates miR146a and miR155 in Activated Microglia Involving STAT3 Signaling
Neurociência · International Journal of Molecular Sciences
Differential Interactions of Flavonoids with the Aryl Hydrocarbon Receptor In Silico and Their Impact on Receptor Activity In Vitro
Medicina · Pharmaceuticals
In vitro anti-parasitic effect of the alkaloids harmaline and piperine on Toxoplasma gondii
Imunologia e microbiologia · Revista Brasileira de Parasitologia Veterinária/Brazilian Journal of Veterinary Parasitology
Neuroprotective Effect of Flavonoid Agathisflavone in the Ex Vivo Cerebellar Slice Neonatal Ischemia
Medicina · Molecules
Methanolic Extract and Brominated Compound from the Brazilian Marine Sponge Aplysina fulva Are Neuroprotective and Modulate Inflammatory Profile of Microglia
Bioquímica, genética e biologia molecular · Marine Drugs
Agathisflavone Modulates Reactive Gliosis After Trauma and Increases the Neuroblast Population at the Subventricular Zone
Medicina · Nutrients
Correlational assessment of the effects of JM-20 in a rat model of parkinsonism
Medicina · Behavioural Brain Research
Three New Polyprenylated Benzophenone Derivatives Isolated from Clusia burle‐marxii
Farmacologia e toxicologia · Chemistry & Biodiversity

2023 8

Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies
Medicina · Pharmaceuticals
Protective Effects of Flavonoid Rutin Against Aminochrome Neurotoxicity
Medicina · Neurotoxicity Research
The Flavonoid Agathisflavone Directs Brain Microglia/Macrophages to a Neuroprotective Anti-Inflammatory and Antioxidant State via Regulation of NLRP3 Inflammasome
Neurociência · Pharmaceutics
THE FLAVONOID AGATHISFLAVONE DIRECTS MICROGLIA TO AN ANTIOXIDANT AND ANTI-INFLAMMATORY STATUS VIA REGULATION OF NLRP3 INFLAMMASOME, THAT IS NEUROPROTECTIVE.
Neurociência · IBRO Neuroscience Reports
Impact of Plant-Derived Compounds on Amyotrophic Lateral Sclerosis
Medicina · Neurotoxicity Research
Amburana cearensis seed extract stimulates astrocyte glutamate homeostatic mechanisms in hippocampal brain slices and protects oligodendrocytes against ischemia
Neurociência · BMC Complementary Medicine and Therapies
MOLECULAR MECHANISMS IN PARKINSON’S DISEASE AND POTENTIAL USE OF NATURAL COMPOUNDS
Medicina · IBRO Neuroscience Reports
Pedagogical insights from immune responses: analyzing Covid-19's severity through systemic immune-inflammation indexes and gene expressions
Medicina · Caderno Pedagógico

2022 5

Neuroimmunomodulatory Properties of Flavonoids and Derivates: A Potential Action as Adjuvants for the Treatment of Glioblastoma
Medicina · Pharmaceutics
Pharmacological Potential of Flavonoids against Neurotropic Viruses
Medicina · Pharmaceuticals
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
Medicina · Neurotoxicity Research
Neurological Infection, Kynurenine Pathway, and Parasitic Infection by Neospora caninum
Neurociência · Frontiers in Immunology
Agathisflavone as a Single Therapy or in Association With Mesenchymal Stem Cells Improves Tissue Repair in a Spinal Cord Injury Model in Rats
Medicina · Frontiers in Pharmacology

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