Emmanuel Silva Marinho

Universidade Estadual do Ceará · CE · 162 publicações em 2022–2026

Computational Drug Discovery MethodsHeterocyclic Compound Synthesis and BioactivityAntimicrobial Resistance in StaphylococcusEssential Oils and Antimicrobial ActivityAntibiotic Resistance in Bacteria

Principais coautores no Nordeste tamanho = publicações em comum

Hélcio Silva dos Santos Márcia Machado Marinho Matheus Nunes da Rocha Jane Eire Silva Alencar de Menezes Alexandre Magno Rodrigues Teixeira Henrique Douglas Melo Coutinho Maria Kueirislene Amâncio Ferreira Jacilene Silva Aluísio Marques da Fonseca Ramon Róseo Paula Pessoa Bezerra de Menezes Victor Moreira de Oliveira Selene Maia de Morais

Publicações recentes

2026 34

Adjuvant Activity and Resistance-Modifying Capacity of a Novel Heterocyclic Hydrazone Derived from the Drug Hydralazine in NorA and MepA Efflux Pumps of Staphylococcus aureus
Medicina · Drugs and Drug Candidates
Coumarin-based multimodal dual-target ligands for MAOB and 5-HT2CR: DFT analysis, QED scoring, molecular docking, and narcosis evaluation
Farmacologia e toxicologia · Journal of the Iranian Chemical Society
Targeting of Leishmania proteins by β-Lapachone derivatives reveals a promising multitarget candidate
Farmacologia e toxicologia · Archives of Microbiology
Bioactive flavonoids from Anacardium occidentale as promising natural inhibitors of Cryptococcus neoformans: a computational perspective on secondary metabolites against critical fungal pathogens
Farmacologia e toxicologia · Archives of Microbiology
In silico analysis of Anacardium occidentale phytochemicals: pharmacokinetics, molecular docking, and dynamics of Cryptococcus neoformans enzymes
Farmacologia e toxicologia · In Silico Pharmacology
Machine learning–guided QSAR screening of fluconazole analogs and FDA-approved drugs against Candida albicans, with docking, molecular dynamics, and ADMET analysis
Farmacologia e toxicologia · Molecular Diversity
Molecular Docking and Dynamics Simulations of Natural Limonoids Interacting with the Nipah Virus Attachment Glycoprotein
Farmacologia e toxicologia · Current Drug Targets
Natural chlocarbazomycins as potential adenosine A1 receptor antagonists: ligand-based and structure-based virtual screening, quantum chemical analysis and CNS MPO study
Farmacologia e toxicologia · Molecular Diversity
Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery
Farmacologia e toxicologia · ChemistrySelect
Europium Metal Complex [Eu(dbm) 3 .LAP] Promotes Antinociceptive Behavior via TRPA1 Neuromodulation and an Anti‐Inflammatory Effect in Adult Zebrafish
Neurociência · Chemistry & Biodiversity
Antibiofilm biosynthetic terpene derivatives against clinically and food-relevant bacteria, including synergistic interactions with β -lactam antibiotics: quantum chemical calculations, molecular docking and ADMET study
Ciências agrárias e biológicas · Biofouling
Evaluation of the antimicrobial and NorA and MepA efflux pump inhibitory activity of a hydrazone derivative of hydralazine against Staphylococcus aureus
Medicina · Archives of Microbiology
LASSBio-1986 as a Multifunctional Antidiabetic Lead: SGLT1/2 Docking, Redox–Inflammatory Modulation and Metabolic Benefits in C57BL/6 Mice
Medicina · International Journal of Molecular Sciences
Chemical Composition, Antifungal Activity and Molecular Docking Study of Essential oil of Rhabdocaulon lavanduloides Benth
Ciências agrárias e biológicas · Natural Product Communications
GABAergic Modulation and Neurobehavioral Effects of Arjunolic Acid, a Pentacyclic Triterpene Isolated From Combretum Mellifluum Eichler: In Vivo and Molecular Docking Evaluation
Medicina · Chemistry & Biodiversity
[Lys3, Lys4] M-PONTX-Dq3a [1–15]: a selective dinoponeratoxin-derived peptide that disrupts parasite membranes and inhibits TcGAPDH activity in Trypanosoma cruzi
Medicina · Toxicon
Multi-Target Analysis of Xanthone Derivatives as Potential Anti-Trypanosoma cruzi Agents: An Integrated Computational Screening
Farmacologia e toxicologia · Journal of Pharmaceutical Innovation
Antiviral and larvicidal properties of Eucalyptus staigeriana essential oil and its monoterpenes 1,8-cineole and +limonene against Zika virus and Aedes spp
Ciências agrárias e biológicas · OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA
Evidence for the Induction of Anxiolytic‐Like Behavior and Memory Preservation by (+)‐Dihydrocarvone Through Studies in Adult Zebrafish and In Sílico
Bioquímica, genética e biologia molecular · Chemistry & Biodiversity
Molecular insights and ADMET profiling of iridoids as candidate leads for erectile dysfunction therapy
Farmacologia e toxicologia · Journal of Molecular Modeling
Electron donating and withdrawing groups affect the antioxidant activity of 4′-aminochalcones on gentamicin-induced kidney cell injury
Farmacologia e toxicologia · Biological Chemistry
Anticandidal, molecular docking, antioxidant, and cytotoxic effects of the essential oil of Vitex gardneriana Schauer
Ciências agrárias e biológicas · Anais da Academia Brasileira de Ciências
Anxiolytic and Memory Protective Effects of Withanolide D Isolated From Acnistus arborescens in Adult Zebrafish
Medicina · Chemistry & Biodiversity
Inhibition of acetylcholinesterase by Cenostigma pyramidale leaf extract: Chemical composition, antioxidant potential, and in vitro–in silico insights
Medicina · Anais da Academia Brasileira de Ciências
Molecular and structural insights into carvacrol and thymol alkylated derivatives targeting WSSV and AHPND-causing Vibrio parahaemolyticus
Farmacologia e toxicologia · Archives of Microbiology
In Vitro and In Silico Evaluation of the Potentiating Effect of Thiadiazine Derivatives Against Multidrug-Resistant (MDR) Bacterial Strains
Medicina · Antibiotics
Prodrug-like Quinone Containing Two Redox-Active Centers Induces Ferroptosis in Prostate Cancer Cells with Cytotoxic Action Partially Depending on NAD(P)H Quinone Dehydrogenase 1 (NQO1)
Farmacologia e toxicologia · ACS Omega
Unraveling therapeutic potential of curcuminoids in anxiety, seizure, and cognitive impairment in a zebrafish model
Bioquímica, genética e biologia molecular · Chemical Papers
Evaluation of Chalcone ( E )-3-(4-Fluorophenyl)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-prop-2-en-1-one against Trypanosoma cruzi (Y Strain): In Vitro Assay, In Silico Drug-Target Analysis, and MPO-Based Drug Likeness
Medicina · ACS Omega
Fungal biofilms and pleomorphism under the effect of sesquiterpenes valencene and nootkatone: an in vitro and in silico approach
Medicina · Microbial Pathogenesis
Synthesis, Structural Characterization, and Evaluation of the Antibacterial Activity of Chalcones Against Staphylococcus aureus Strains Overexpressing the NorA and MepA Efflux Pumps: An In Vitro, In Silico, and Molecular Approach
Medicina · ChemistrySelect
Structural insights into the structure–activity relationships of flavonoids targeting WSSV and LvGSTMu
Farmacologia e toxicologia · Molecular Diversity
UPLC-ESI-QToF-MS/MS profiling and anxiolytic-like effects of Simira paraensis (Baill.) Steyerm bark
Medicina · Journal of Pharmaceutical and Biomedical Analysis
α‐Glucosidase and Acetylcholinesterase (AChE) Inhibitory Activities, Larvicidal Potential and GC–MS Analysis of Endlicheria paniculata : A Combined Experimental and Molecular Docking Study
Ciências agrárias e biológicas · Chemistry & Biodiversity

2025 16

Naringenin as potentiator of norfloxacin efficacy through inhibition of the NorA efflux pump in Staphylococcus aureus
Medicina · Microbial Pathogenesis
Investigation of the anti-leishmanial potential of triazole-linked carvacrol–coumarin derivatives: a docking, molecular dynamics, MM/GBSA toxicity approach
Farmacologia e toxicologia · Journal of the Iranian Chemical Society
Evaluation of the antibacterial and inhibitory activity of the NorA and TetK efflux pumps of Staphylococcus aureus by p-coumaric acid
Medicina · Microbial Pathogenesis
Evaluation of the intrinsic antibacterial and antibiotic potentiating activity against antibiotic resistance in Staphylococcus aureus and inhibition of the NorA and MepA efflux pumps by a hydrazone derivative of isoniazid
Medicina · Microbial Pathogenesis
In silico activity and effect of synthetic chalcones on Candida albicans and Candida tropicalis biofilms
Medicina · Biochimie
Evaluation of the antibacterial and efflux inhibitory activity of trans-cinnamic acid in Staphylococcus aureus: Experimental assays and in silico modeling
Medicina · Phytomedicine Plus
Chemical Composition and Larvicidal Activity Against Aedes aegypti of the Leaf Essential Oils from Croton blanchetianus
Ciências agrárias e biológicas · Molecules
Neuropharmacological evaluation of hydralazine hydrazone derivatives: Synthesis, In silico, and zebrafish studies
Bioquímica, genética e biologia molecular · Biochemical and Biophysical Research Communications
Phenol and chromone compounds for in silico inhibition of nsP2 and nsP3 of Chikungunya virus
Farmacologia e toxicologia · Pharmaceutical Science Advances
Antibacterial and Antibiofilm Activities of Hydralazine, an Antihypertensive Drug: In Vitro and In Silico Approaches
Bioquímica, genética e biologia molecular · Antibiotics
Insights of potential action with acyclovir analogs for the control of white spot syndrome virus (WSSV): Molecular dynamics and ecotoxicological analysis approach
Imunologia e microbiologia · Microbial Pathogenesis
Assessment of MepA inhibition potential using thiadiazine derivatives through fluorometry, docking, and qPCR
Medicina · Gene Reports
Synthesis, Characterization, and Evaluation of the Anxiolytic Activity of Hydrazones Derived from the Drug Isoniazid, Using the Adult Zebrafish (Danio rerio) Model
Bioquímica, genética e biologia molecular · ACS Omega
Bioactive structures for inhibitors of Candida auris polymerase enzyme by artificial intelligence
Farmacologia e toxicologia · Future Medicinal Chemistry
Antioxidant Activity and Anxiolytic Effect of Cnidoscolus quercifolius Pohl Stem Bark Extract in Zebrafish
Ciências agrárias e biológicas · Future Pharmacology
Serotonergic Neuromodulation of Natural Products Isoreserpine and Isoreserpiline in Adult Zebrafish: An in Silico and In Vivo Investigation
Medicina · Chemistry & Biodiversity

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