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HC

Henrique Douglas Melo Coutinho

Universidade Regional do Cariri · CE · 358 publicações em 2022–2026

ORCID 0000-0002-6634-4207

Essential Oils and Antimicrobial ActivityPhytochemistry Medicinal Plant ApplicationsMedicinal Plant ResearchAntibiotic Resistance in BacteriaAntimicrobial Resistance in Staphylococcus

Principais coautores no Nordeste tamanho = publicações em comum

Irwin Rose Alencar de Menezes Maria Flaviana Bezerra Morais‐Braga Cícera Datiane de Morais Oliveira–Tintino José Weverton Almeida‐Bezerra Saulo Relison Tintino Janaína Esmeraldo Rocha Hélcio Silva dos Santos Isaac Moura Araújo Thiago Sampaio de Freitas Emmanuel Silva Marinho Gabriel Gonçalves Alencar José Maria Barbosa‐Filho

Publicações recentes

2026 39

Antifungal Efficacy against Candida spp. Strains and Synthesis via Heck–Matsuda Arylation of Aryl-Camphene-Type Derivatives
Medicina · ACS Omega
Adjuvant Activity and Resistance-Modifying Capacity of a Novel Heterocyclic Hydrazone Derived from the Drug Hydralazine in NorA and MepA Efflux Pumps of Staphylococcus aureus
Medicina · Drugs and Drug Candidates
Chemical composition and biological activities of Momordica charantia leaves: a review
Ciências agrárias e biológicas · Phytochemistry Reviews
Nanostructured Lipid Carriers Containing Norfloxacin and 2-Aminothiophene Derivative Reduces Fluoroquinolone Resistance in Multidrug-Resistant Staphylococcus aureus Strains by Efflux Pump Inhibition
Farmacologia e toxicologia · Pharmaceutics
Lupeol as a modulator of bacterial resistance mediated by the MepA efflux pump in Staphylococcus aureus
Medicina · Naunyn-Schmiedeberg s Archives of Pharmacology
Co‐Occurrence of Resistance to Aminoglycosides and Carbapenems in Klebsiella pneumoniae : A Critical Threat to Public Health
Medicina · International Journal of Microbiology
Advances in Natural Products and Their Biological Activities
Farmacologia e toxicologia · Molecules
Lippia grata Schauer: Essential Oil as a Source of the Phytotherapeutic Thymol for the Treatment of Seizures and Anxiety Induced by Alcohol Withdrawal in Adult Zebrafish
Medicina · Chemistry & Biodiversity
In vitro and in vivo evaluation of antibacterial activity of 1,8-cineol and the essential oil of Myrciaria pilosa Sobral & Couto
Ciências agrárias e biológicas · Microbial Pathogenesis
Anti-nociceptive property of thymol: animal study with molecular docking and MD simulation studies
Medicina · In Silico Pharmacology
In vitro ontogeny and chemical constituents of Polystichum palniense gametophyte and sporophyte ethanolic extracts
Ciências agrárias e biológicas · Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology
ADMET Study of Synthetic Chalcones and Their In Vitro Inhibitory Effect on the Morphological Transition of Candida albicans and Candida tropicalis
Medicina · Cellular Microbiology
Adjuvant Effect of Meldrum’s Acid Derivatives on Antibiotic Activity Against Multidrug-Resistant Bacteria
Imunologia e microbiologia · International Journal of Molecular Sciences
UPLC‐QTOF‐MS/MS and Antifungal Activity of a Fraction Enriched in Saponins From Sarcomphalus joazeiro Against Candida spp
Medicina · Biomedical Chromatography
Modulatory effect of Canavalia gladiata lectin on quinolone activity against multidrug-resistant and efflux pump-positive Staphylococcus aureus
Medicina · Frontiers in Pharmacology
Neuropharmacological effects of the crude ethanolic extract from aerial parts of Passiflora cincinnataMast. (Passifloraceae) and possible mechanisms of action involved
Medicina · Boletin Latinoamericano y del Caribe de plantas Medicinales y Aromaticas
Repellent activity and toxicity of the essential oil of Calyptranthes concinna DC. using the model insect Drosophila melanogaster
Ciências agrárias e biológicas · Revista Brasileira de Botânica
Hepatotoxicity of anti-tuberculosis therapy and the hepatoprotective effect of traditional medicine
Farmacologia e toxicologia · Food and Humanity
Chemical synthesis and evaluation of the antibacterial activity of the amino chalcone in efflux pump-carrying strains
Medicina · FEMS Microbiology Letters
Evaluation of the effects of hybrids of metronidazole and eugenol analogues as inhibitors of the Staphylococcus aureus NorA efflux pump: an in vitro and in silico analysis
Medicina · Folia Microbiologica
In vitro propagation and developmental ontogeny of endemic fern Anemia schimperiana C. Presl subsp. Wightiana (Gardener) fraser-jenk. (Anemiaceae) and tree fern Cyathea gigantea (Wall. Ex Hook.) holtt (Cyatheaceae)
Ciências agrárias e biológicas · In Vitro Cellular & Developmental Biology - Plant
Phytochemical and antioxidant analysis of flour obtained from the pulp of Mauritia flexuosa L. (Arecaceae) and its application in bread preparation
Medicina · Food and Humanity
Modulatory effect of Piper urophyllum C.DC essential oil on antibiotics and chlorhexidine: implications for low-cost mouthrinse development
Ciências agrárias e biológicas · Vegetos
Eugenol‐Based Thiazole Derivatives Inhibit the MepA Efflux Pump in Staphylcoccus aureus
Medicina · ChemistrySelect
Establishing a Zebrafish (Danio rerio) infection model to assess antimicrobial treatment efficacy against Staphylococcus aureus expressing the NorA efflux pump
Medicina · Biologia
Comparative analysis of the antifungal potential of Ocimum basilicum essential oil, estragole, and its estragole/β-cyclodextrin complex in an adult zebrafish infection model
Ciências agrárias e biológicas · South African Journal of Botany
Modifying Effect of the Antibiotic Action, Membrane Permeability, and ADMET/Toxicity Profile of the Fixed Oil From the Pulp of Mauritia Flexuosa F.L. (Arecaceae)
Ciências agrárias e biológicas · Chemistry & Biodiversity
Fungistatic potential and inhibition of fungal yeast-hyphae switch of Candida spp. by hecogenin acetate
Medicina · FEMS Microbiology Letters
Gastroprotective Effects of Hexanic Extract of the Leaves of Spondias purpurea and Its Underlying Mechanism of Action
Ciências agrárias e biológicas · Journal of Food Process Engineering
Metronidazole and Eugenol Hybrids as an Alternative Against Multidrug‐Resistant Bacteria
Ciências agrárias e biológicas · ChemistrySelect
In Vitro and In Silico Evaluation of the Potentiating Effect of Thiadiazine Derivatives Against Multidrug-Resistant (MDR) Bacterial Strains
Medicina · Antibiotics
Himatanthus drasticus (Mart.) Plumel (APOCYNACEAE): phytochemical profile, evaluation of antibacterial and drug-potentiating activity, and toxicity of stem bark extracts
Ciências agrárias e biológicas · Vegetos
Use of Pequi Pie ( Caryocar coriaceum Wittm.) and Flour to the Development of Culinary Spice in Tablet
Ciências agrárias e biológicas · Journal of Food Process Engineering
Fungal biofilms and pleomorphism under the effect of sesquiterpenes valencene and nootkatone: an in vitro and in silico approach
Medicina · Microbial Pathogenesis
Multifunctional molecular encapsulating agents – Cyclodextrins: Physicochemical properties, safety, solubility, bioavailability and applications in pharmaceuticals and foods
Farmacologia e toxicologia · Biomaterials Advances
Antibacterial activity of geraniol in prevalent and resistant bacteria of the oral microbiota of patients
Ciências agrárias e biológicas · FEMS Microbiology Letters
Synthesis, Structural Characterization, and Evaluation of the Antibacterial Activity of Chalcones Against Staphylococcus aureus Strains Overexpressing the NorA and MepA Efflux Pumps: An In Vitro, In Silico, and Molecular Approach
Medicina · ChemistrySelect
Evaluation of the antimicrobial and NorA and MepA efflux pump inhibitory activity of a hydrazone derivative of hydralazine against Staphylococcus aureus
Medicina · Archives of Microbiology
Daidzin and Phytol Enhance the Sedative Effect of Diazepam and the Anesthetic Effects of Thiopental Sodium: In Vivo and Computational Assessments
Medicina · Iranian Journal of Science

2025 11

Naringenin as potentiator of norfloxacin efficacy through inhibition of the NorA efflux pump in Staphylococcus aureus
Medicina · Microbial Pathogenesis
Anticancer activity of Jasminum sambac and its bioactive phytochemicals against the PI3K-AKT-mTOR pathway: A literature-based in silico study
Farmacologia e toxicologia · South African Journal of Botany
Evaluation of the antibacterial and inhibitory activity of the NorA and TetK efflux pumps of Staphylococcus aureus by p-coumaric acid
Medicina · Microbial Pathogenesis
ADME/Tox study and the effect of β-Caryophyllene on the resistant strain of Staphylococcus aureus carrying the QacA/B efflux pump gene
Ciências agrárias e biológicas · Toxicology Reports
Chemical composition and pharmacological activities of Ficus racemosa fruit methanolic extract
Ciências agrárias e biológicas · Pharmacological Research - Natural Products
Evaluation of the intrinsic antibacterial and antibiotic potentiating activity against antibiotic resistance in Staphylococcus aureus and inhibition of the NorA and MepA efflux pumps by a hydrazone derivative of isoniazid
Medicina · Microbial Pathogenesis
Antimicrobial potentials and challenges of paracetamol: A comprehensive reassessment based on database reports
Imunologia e microbiologia · Pharmaceutical Science Advances
In silico activity and effect of synthetic chalcones on Candida albicans and Candida tropicalis biofilms
Medicina · Biochimie
Antifungal Action of Valencene and Nootkatone Compounds in Association with Fluconazole and Their Mechanism of Action Against Candida spp. and Pichia kudriavzevii Strains
Medicina · Current Microbiology
Evaluation of the antibacterial and efflux inhibitory activity of trans-cinnamic acid in Staphylococcus aureus: Experimental assays and in silico modeling
Medicina · Phytomedicine Plus
Chemical characterization, antibacterial and antifungal activity of honey pots and pollen pots obtained from the stingless bee Tetragonisca angustula (Latreille, 1811)
Ciências agrárias e biológicas · Food and Chemical Toxicology

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