Hélcio Silva dos Santos

Universidade Estadual Vale do Acaraú · CE · 162 publicações em 2022–2026

Essential Oils and Antimicrobial ActivityHeterocyclic Compound Synthesis and BioactivityComputational Drug Discovery MethodsZebrafish Biomedical Research ApplicationsAntibiotic Resistance in Bacteria

Principais coautores no Nordeste tamanho = publicações em comum

Emmanuel Silva Marinho Márcia Machado Marinho Jane Eire Silva Alencar de Menezes Henrique Douglas Melo Coutinho Matheus Nunes da Rocha Alexandre Magno Rodrigues Teixeira Maria Kueirislene Amâncio Ferreira Antônio Wlisses da Silva Francisco Rogênio da Silva Mendes Aluísio Marques da Fonseca Janaína Esmeraldo Rocha Ramon Róseo Paula Pessoa Bezerra de Menezes

Publicações recentes

2026 24

Adjuvant Activity and Resistance-Modifying Capacity of a Novel Heterocyclic Hydrazone Derived from the Drug Hydralazine in NorA and MepA Efflux Pumps of Staphylococcus aureus
Medicina · Drugs and Drug Candidates
Assessment of the Acute Toxicity and Anxiolytic‐Like Effect of α‐ Humulene in Adult Zebrafish ( Danio rerio )
Medicina · Chemistry & Biodiversity
Molecular Docking and Dynamics Simulations of Natural Limonoids Interacting with the Nipah Virus Attachment Glycoprotein
Farmacologia e toxicologia · Current Drug Targets
Antibiofilm biosynthetic terpene derivatives against clinically and food-relevant bacteria, including synergistic interactions with β -lactam antibiotics: quantum chemical calculations, molecular docking and ADMET study
Ciências agrárias e biológicas · Biofouling
Synthesis, Structural Characterization, and Evaluation of the Antibacterial Activity of Chalcones Against Staphylococcus aureus Strains Overexpressing the NorA and MepA Efflux Pumps: An In Vitro, In Silico, and Molecular Approach
Medicina · ChemistrySelect
Integrated quantum chemical calculations and in silico approach to the anxiolytic effects of campesterol and its derivatives, with evaluation of locomotor activity in adult zebrafish (Danio rerio)
Bioquímica, genética e biologia molecular · Chemical Papers
Chemical synthesis and evaluation of the antibacterial activity of the amino chalcone in efflux pump-carrying strains
Medicina · FEMS Microbiology Letters
ADMET Study of Synthetic Chalcones and Their In Vitro Inhibitory Effect on the Morphological Transition of Candida albicans and Candida tropicalis
Medicina · Cellular Microbiology
Isothiocyanate-Rich Essential Oil of Morisonia flexuosa L. Exhibits Anxiolytic-like Effects That May Involve Serotonergic Pathways in Zebrafish
Medicina · Plants
Evidence for the Induction of Anxiolytic‐Like Behavior and Memory Preservation by (+)‐Dihydrocarvone Through Studies in Adult Zebrafish and In Sílico
Bioquímica, genética e biologia molecular · Chemistry & Biodiversity
Electron donating and withdrawing groups affect the antioxidant activity of 4′-aminochalcones on gentamicin-induced kidney cell injury
Farmacologia e toxicologia · Biological Chemistry
Antibacterial and Antibiofilm Activities of Croton pluriglandulosus Carn.-Torres & Riina. Essential Oil and Its Membrane-Disruptive Effects
Ciências agrárias e biológicas · Processes
Editorial - Mechanisms of Action of Natural Products Against Resistant Microorganisms
Ciências agrárias e biológicas · Natural Product Communications
LASSBio-1986 as a Multifunctional Antidiabetic Lead: SGLT1/2 Docking, Redox–Inflammatory Modulation and Metabolic Benefits in C57BL/6 Mice
Medicina · International Journal of Molecular Sciences
Evaluation of the antimicrobial and NorA and MepA efflux pump inhibitory activity of a hydrazone derivative of hydralazine against Staphylococcus aureus
Medicina · Archives of Microbiology
In Vitro and In Silico Evaluation of the Potentiating Effect of Thiadiazine Derivatives Against Multidrug-Resistant (MDR) Bacterial Strains
Medicina · Antibiotics
Europium Metal Complex [Eu(dbm) 3 .LAP] Promotes Antinociceptive Behavior via TRPA1 Neuromodulation and an Anti‐Inflammatory Effect in Adult Zebrafish
Neurociência · Chemistry & Biodiversity
UPLC-ESI-QToF-MS/MS profiling and anxiolytic-like effects of Simira paraensis (Baill.) Steyerm bark
Medicina · Journal of Pharmaceutical and Biomedical Analysis
GABAergic Modulation and Neurobehavioral Effects of Arjunolic Acid, a Pentacyclic Triterpene Isolated From Combretum Mellifluum Eichler: In Vivo and Molecular Docking Evaluation
Medicina · Chemistry & Biodiversity
Evaluation of Chalcone ( E )-3-(4-Fluorophenyl)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-prop-2-en-1-one against Trypanosoma cruzi (Y Strain): In Vitro Assay, In Silico Drug-Target Analysis, and MPO-Based Drug Likeness
Medicina · ACS Omega
Chemical properties and biological evaluation of pectin from pequi external mesocarp
Ciências agrárias e biológicas · Journal of Food Measurement & Characterization
Anxiolytic and Memory Protective Effects of Withanolide D Isolated From Acnistus arborescens in Adult Zebrafish
Medicina · Chemistry & Biodiversity
α‐Glucosidase and Acetylcholinesterase (AChE) Inhibitory Activities, Larvicidal Potential and GC–MS Analysis of Endlicheria paniculata : A Combined Experimental and Molecular Docking Study
Ciências agrárias e biológicas · Chemistry & Biodiversity
Unraveling therapeutic potential of curcuminoids in anxiety, seizure, and cognitive impairment in a zebrafish model
Bioquímica, genética e biologia molecular · Chemical Papers

2025 26

Naringenin as potentiator of norfloxacin efficacy through inhibition of the NorA efflux pump in Staphylococcus aureus
Medicina · Microbial Pathogenesis
Investigation of the anti-leishmanial potential of triazole-linked carvacrol–coumarin derivatives: a docking, molecular dynamics, MM/GBSA toxicity approach
Farmacologia e toxicologia · Journal of the Iranian Chemical Society
Evaluation of the antibacterial and inhibitory activity of the NorA and TetK efflux pumps of Staphylococcus aureus by p-coumaric acid
Medicina · Microbial Pathogenesis
In silico activity and effect of synthetic chalcones on Candida albicans and Candida tropicalis biofilms
Medicina · Biochimie
Evaluation of the intrinsic antibacterial and antibiotic potentiating activity against antibiotic resistance in Staphylococcus aureus and inhibition of the NorA and MepA efflux pumps by a hydrazone derivative of isoniazid
Medicina · Microbial Pathogenesis
Chemical Composition and Larvicidal Activity Against Aedes aegypti of the Leaf Essential Oils from Croton blanchetianus
Ciências agrárias e biológicas · Molecules
Neuropharmacological evaluation of hydralazine hydrazone derivatives: Synthesis, In silico, and zebrafish studies
Bioquímica, genética e biologia molecular · Biochemical and Biophysical Research Communications
Antibacterial and Antibiofilm Activities of Hydralazine, an Antihypertensive Drug: In Vitro and In Silico Approaches
Bioquímica, genética e biologia molecular · Antibiotics
Assessment of MepA inhibition potential using thiadiazine derivatives through fluorometry, docking, and qPCR
Medicina · Gene Reports
Antioxidant Activity and Anxiolytic Effect of Cnidoscolus quercifolius Pohl Stem Bark Extract in Zebrafish
Ciências agrárias e biológicas · Future Pharmacology
Bioactive structures for inhibitors of Candida auris polymerase enzyme by artificial intelligence
Farmacologia e toxicologia · Future Medicinal Chemistry
Synthesis, Characterization, and Evaluation of the Anxiolytic Activity of Hydrazones Derived from the Drug Isoniazid, Using the Adult Zebrafish (Danio rerio) Model
Bioquímica, genética e biologia molecular · ACS Omega
Editorial: Approaches to improve the performance of virtual screening: scoring functions, structural filtration, prediction of physicochemical properties/pharmacological activity
Farmacologia e toxicologia · Frontiers in Pharmacology
Coumarin benzamide scaffold as potential 5-HT2C inhibitors: a multiparametric investigation and molecular simulation
Farmacologia e toxicologia · Journal of Molecular Modeling
Serotonergic Neuromodulation of Natural Products Isoreserpine and Isoreserpiline in Adult Zebrafish: An in Silico and In Vivo Investigation
Medicina · Chemistry & Biodiversity
Evaluation of the Anxiolytic and Anticonvulsant Effect of Marlierea eugeniopsoides Essential Oils and Its Majority Constituents in Adult Zebrafish
Medicina · Chemistry & Biodiversity
Searching for Hypoglycemic Compounds from Brazilian Medicinal Plants Through UPLC-HRMS and Molecular Docking
Medicina · Plants
Electronic properties and adjuvant effect of riparins I-IV: Inhibition of β-lactamase and QacC efflux pump in Staphylococcus aureus K4100
Medicina · Biochemical and Biophysical Research Communications
In Vitro and In Silico Study of the Inhibitory Potential of Riparins I, II, III, and IV on the NorA Efflux Pump of Staphylococcus aureus
Medicina · ChemistrySelect
Evaluation of the Activity of Amino Chalcone Against Staphylococcus Strains Harboring Efflux Pumps
Medicina · Pharmaceuticals
Anxiety behavior in adult Zebrafish modulated by the alkaloid fraction of Cissampelos sympodialis Eichl. roots
Medicina · Phytomedicine Plus
A phenolic ether 2-methoxy-carvacrol isolated from Rhabdocaulon lavanduloides (Benth) Epling. (Lamiaceae): New crystal structure, Hirshfeld surface, quantum chemical calculation, anxiolytic and anticonvulsant potential in zebrafish, and molecular docking of GABAA receptor
Medicina · Journal of Molecular Structure
Chalcone Derived from a Natural Product: An Integrated Approach of Quantum Chemical Calculations, Molecular Docking, ADME and Neuromodulation on Serotonergic Receptors in Adult Zebrafish
Medicina · Journal of Pharmacy and Nutrition Sciences
Synthesis and anthelmintic activity of aminochalcones against multiresistant Haemonchus contortus
Imunologia e microbiologia · Revista Brasileira de Parasitologia Veterinária/Brazilian Journal of Veterinary Parasitology
Unraveling the Antihyperglycemic Effects of Dipeptyl Peptidase-4 Inhibitors in Rodents: A Multi-Faceted Approach Combining Effects on Glucose Homeostasis, Molecular Docking, and ADMET Profiling
Medicina · Pharmaceuticals
Evaluation of the antibacterial and inhibitory activity of the NorA efflux pump in Staphylococcus aureus by citronellol
Medicina · Biologia

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