Marcus Tullius Scotti

Universidade Federal da Paraíba · PB · 90 publicações em 2022–2026

Computational Drug Discovery MethodsSynthesis and Characterization of Heterocyclic CompoundsHeterocyclic Compound Synthesis and BioactivityResearch on Leishmaniasis StudiesBioactive natural compounds

Principais coautores no Nordeste tamanho = publicações em comum

Luciana Scotti Natália Ferreira de Sousa Renata Priscila Barros de Menezes Josean Fechine Tavares Francisco Jaime Bezerra Mendonça Marcelo Sobral da Silva Pablo Rayff da Silva Cícero Francisco Bezerra Felipe Arthur Lins Dias Hugo Fernandes Oliveira Pires Klinger Antônio da França Rodrigues Mayara dos Santos Maia

Publicações recentes

2026 8

Neuroinflammation in Epilepsy: Biochemical and Molecular Mechanisms and Implications for Natural Product-Driven Drug Discovery
Medicina · International Journal of Molecular Sciences
Redox Disruption Induced by Saquayamycin B1 Promotes Cytotoxicity in Resistant Melanoma Cells
Farmacologia e toxicologia · ChemMedChem
From Xenobiotic Exposure to Neuroinflammation: Mechanisms Linking Lipopolysaccharide Signaling to Depressive-like Behavior
Neurociência · Journal of Xenobiotics
Deciphering the molecular mechanism of sesamol in inflammatory bowel disease through an integrative computational and biological evaluation of the JAK1 signalling pathway
Farmacologia e toxicologia · Naunyn-Schmiedeberg s Archives of Pharmacology
IRACEMA: A Database Management System for Bioactive Compounds Obtained and Characterized by Brazilian Researchers
Farmacologia e toxicologia · ACS Omega
Cannabidiol against Epilepsy: Insights and an Experimental In Silico Approach
Medicina · Current Pharmaceutical Design
Tiliroside From Pavonia malacophylla (Link & Otto) Garcke as an Anti‐SARS‐CoV‐2 Cell Entry Agent
Medicina · Chemistry & Biodiversity
Nose-to-Brain Delivery System for Incorporating Monoterpenes with Anti-Depressant Potential
Medicina · Current Neuropharmacology

2025 24

ADME Properties in Drug Delivery
Farmacologia e toxicologia · Pharmaceutics
Fabaceae Flavonoids Beyond the Commonplace: A Review of Chemical Diversity, Pharmacological Activities, Mass Spectrometric Profiling and In Silico Insights into Their Subclasses
Farmacologia e toxicologia · Plants
2-Aminothiophene Derivatives—New Drug Candidates Against Leishmaniasis: Drug Design, Synthesis, Pharmacomodulation, and Antileishmanial Activity
Medicina · Pharmaceuticals
4-Hydroxycoumarin Exhibits Antinociceptive and Anti-Inflammatory Effects Through Cytokine Modulation: An Integrated In Silico and In Vivo Study
Medicina · International Journal of Molecular Sciences
Host-Mediated Antimicrobial Effects and NLRP3 Inflammasome Modulation by Caulerpin and Its Derivatives in Macrophage Models of Mycobacterial Infections
Medicina · Microorganisms
AmIActive (AIA): A Large-scale QSAR Based Target Fishing and Polypharmacology Predictive Web Tool
Farmacologia e toxicologia · Journal of Molecular Biology
Guanidines Conjugated with Cell-Penetrating Peptides: A New Approach for the Development of Antileishmanial Molecules
Medicina · Molecules
Drug design and synthesis of new N-substituted-thienopyridine based on 2-aminothiophene derivatives as antileishmanial agents
Medicina · Bioorganic & Medicinal Chemistry
Plants Metabolites as In Vitro Inhibitors of SARS-CoV-2 Targets: A Systematic Review and Computational Analysis
Farmacologia e toxicologia · Drugs and Drug Candidates
Exploring Lamiaceae diterpenoids as potential multitarget therapeutics for leishmaniasis and chagas disease
Farmacologia e toxicologia · Molecular Diversity
Repeated-Dose Toxicity of Lauric Acid and Its Preventive Effect Against Tracheal Hyper-Responsiveness in Wistar Rats with Possible In Silico Molecular Targets
Medicina · Pharmaceuticals
Preclinical Evaluation of Selene-Ethylenelacticamides in Tuberculosis: Effects Against Active, Dormant, and Resistant Mycobacterium Tuberculosis and In Vitro Toxicity Investigation
Medicina · Microorganisms
Novel indole-based marinoquinolines as promising candidates against Toxoplasma gondii
Imunologia e microbiologia · European Journal of Medicinal Chemistry
Microglia-Targeted Nanotherapeutics in Major Depressive Disorder: An Integrative Perspective on Neuroinflammation and Drug Delivery
Neurociência · Pharmaceutics
Predicting the Anti-SARS-CoV-2 Potential of Isoquinoline Alkaloids from Brazilian Siparunaceae Species Using Chemometric Tools
Ciências agrárias e biológicas · International Journal of Molecular Sciences
Haemanthidine-Containing Alkaloid Fraction from Crinum scabrum as a Natural Therapeutics for Chagas Disease
Medicina · ACS Omega
Orofacial antinociceptive effect of a novel 2-amino-thiophene derivative and its possible targets of action
Medicina · Brazilian Oral Research
Structure‐based Virtual Screening and Drug Design Development of Leishmanicidal Pyrimidines
Medicina · Chemistry & Biodiversity
Larvicidal potential of Knoevenagel adducts against Aedes aegypti : theoretical study and in vitro validation
Ciências agrárias e biológicas · Future Medicinal Chemistry
Special Issue “The Role of Natural Products in Drug Discovery”
Farmacologia e toxicologia · International Journal of Molecular Sciences
Antibacterial Mechanisms of 4-Chlorobenzyl p-Coumarate: Inhibition of MepA and NorA Efflux Pumps
Medicina · Future Pharmacology
Structure‐Based Screening of Amides with Potential to Overcome Aedes aegypti Insecticide Resistance
Farmacologia e toxicologia · ChemistrySelect
Multiple targets directed screening of compounds from northeastern Brazilian fruits with activity in oxidative stress pathways associated with vascular damage throughout ageing
Farmacologia e toxicologia · Natural Product Research
Chemometric Analysis of Annona Species with Antileishmanial Activity Using Liquid Chromatography Coupled to Mass Spectrometry
Bioquímica, genética e biologia molecular · Revista Brasileira de Farmacognosia

2024 17

Computational and ADMET Predictions of Novel Compounds as Dual Inhibitors of BuChE and GSK-3β to Combat Alzheimer’s Disease
Medicina · Pharmaceutics
In Silico and In Vitro Evaluation of the Antifungal Activity of a New Chromone Derivative against Candida spp.
Medicina · BioTech
Multi-target Phenylpropanoids Against Epilepsy
Farmacologia e toxicologia · Current Neuropharmacology
Myrtucommulones and Related Acylphloroglucinols from Myrtaceae as a Promising Source of Multitarget SARS-CoV-2 Cycle Inhibitors
Ciências agrárias e biológicas · Pharmaceuticals
Anticonvulsant activity of Tetrahydrolinalool: behavioral, electrophysiological, and molecular docking approaches
Medicina · ChemMedChem
First Description of Marinoquinoline Derivatives’ Activity against Toxoplasma gondii
Imunologia e microbiologia · Pharmaceutics
Synthesis, in vitro and in silico evaluation of gallamide and selenogallamide derivatives as inhibitors of the SARS‐CoV‐2 main protease
Medicina · Archiv der Pharmazie
In vitro and in silico evaluation of the anti-leishmania activity of synthetic chalcones
Medicina · Natural Product Research
Multitarget Compounds for Neglected Diseases: A Review
Farmacologia e toxicologia · Current Drug Targets
MuDRA‐Based Virtual Screening of Terpenes for Anti‐Leishmania Infantum Activity: In Vitro Validation and Mechanistic Insights from Molecular Docking
Medicina · ChemMedChem
Inhibitory Effects of Mangifera indica Secondary Metabolites and Their Synthetic Derivatives against SARS-CoV-2 Mpro and NS2B/NS3 (ZIKV and DENV-2)
Medicina · ACS Omega
APRENDIZADO DE MÁQUINA APLICADO A QSAR
Farmacologia e toxicologia · Química Nova
In Silico and In Vitro Studies of Terpenes from the Fabaceae Family Using the Phenotypic Screening Model against the SARS-CoV-2 Virus
Farmacologia e toxicologia · Pharmaceutics
Enzymatic Targets in the Anticancer Drug Discovery
Bioquímica, genética e biologia molecular · Current Protein and Peptide Science
Development of a standardized methodology for transfer learning with QSAR models: a purely data-driven approach for source task selection
Farmacologia e toxicologia · SAR and QSAR in environmental research
Synergistic effect of new pyrimidine derivative with oxacilin against methicillin-resistant Staphylococcus aureus
Medicina · Future Medicinal Chemistry
Recent Medicinal Chemistry Studies on Neglected Diseases
Farmacologia e toxicologia · Combinatorial Chemistry & High Throughput Screening

2023 1

Elucidating the molecular mechanisms of essential oils' insecticidal action using a novel cheminformatics protocol
Ciências agrárias e biológicas · Scientific Reports

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