Francisco Jaime Bezerra Mendonça

Universidade Estadual da Paraíba · PB · 47 publicações em 2022–2026

docente de pós-graduaçãobolsa de produtividade 2ORCID 0000-0001-5738-797X

Computational Drug Discovery MethodsHeterocyclic Compound Synthesis and BioactivitySynthesis and Characterization of Heterocyclic CompoundsResearch on Leishmaniasis StudiesTrypanosoma species research and implications

Programas de pós-graduação (CAPES)

6Produtos naturais e sintéticos bioativosUFPB-JOÃO PESSOA · docente permanente (2024)

Principais coautores no Nordeste tamanho = publicações em comum

Edeildo Ferreira da Silva‐Júnior Thiago Mendonça de Aquino João Xavier de Araújo‐Júnior Rodrigo Santos Aquino de Araújo Igor José dos Santos Nascimento Klinger Antônio da França Rodrigues Marcus Tullius Scotti Henrique Douglas Melo Coutinho Luciana Scotti Valnês S. Rodrigues-Junior Ana Carolina Justino de Araújo Cícera Datiane de Morais Oliveira–Tintino

Orientações concluídas (CAPES)

PREPARAÇÃO, CARACTERIZAÇÃO FÍSICO-QUÍMICA E AVALIAÇÃO IN VITRO DA ATIVIDADE ANTI-LEISHMANIA DE NANOPARTÍCULAS DE PLA ENCAPSULADAS COM O DERIVADO 2 AMINO TIOFÊNICO SB83
dissertação · IZABELE DE SOUZA ARAUJO · PRODUTOS NATURAIS E SINTÉTICOS BIOATIVOS · 2024
SÍNTESE DE DERIVADOS CHALCONAS E BICHALCONAS COM AVALIAÇÃO DA ATIVIDADE LEISHMANICIDA E ANTITUMORAL
tese · FERNANDO FERREIRA LEITE · PRODUTOS NATURAIS E SINTÉTICOS BIOATIVOS · 2024
PLANEJAMENTO, SÍNTESE E AVALIAÇÃO DO POTENCIAL ANTILEISHMANIA DE NOVOS 2-AMINOTIOFENO-3-CARBOXAMIDAS OBTIDAS POR MODIFICAÇÃO MOLECULAR
dissertação · MIRLA MIRELY DANTAS FERREIRA · PRODUTOS NATURAIS E SINTÉTICOS BIOATIVOS · 2022
PLANEJAMENTO, SÍNTESE E AVALIAÇÃO DO POTENCIAL DE NOVOS 2-AMINOSELENOFENOS COMO CANDIDATOS A FÁRMACOS LEISHMANICIDAS
dissertação · ROBERT DA SILVA TIBURCIO · PRODUTOS NATURAIS E SINTÉTICOS BIOATIVOS · 2022

Publicações recentes

2026 11

QSAR-based drug discovery of 2-((4-Imino-3,4-dihydroquinazolin-2-yl)thio-substituted analogs targeting Mycobacterium tuberculosis
Farmacologia e toxicologia · Bioorganic & Medicinal Chemistry
2-Aminothiophene Derivative SB-83 Inhibits Trypanothione Reductase and Modulates Cytokine Production in Trypanosoma cruzi-Infected Cells
Medicina · Pathogens
5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine-based thiosemicarbazones as anti-Trypanosoma cruzi agents
Medicina · Bioorganic & Medicinal Chemistry
Nanostructured Lipid Carriers Containing Norfloxacin and 2-Aminothiophene Derivative Reduces Fluoroquinolone Resistance in Multidrug-Resistant Staphylococcus aureus Strains by Efflux Pump Inhibition
Farmacologia e toxicologia · Pharmaceutics
In Vitro and In Silico Evaluation of the Potentiating Effect of Thiadiazine Derivatives Against Multidrug-Resistant (MDR) Bacterial Strains
Medicina · Antibiotics
Guanidines: Privileged Scaffolds Against Neglected Tropical Diseases: A Review
Medicina · Pharmaceuticals
Insights into a new class of antileishmanial compounds: an in vitro and in silico study of 1,2,4-oxadiazol-5(4H)-one derivatives
Medicina · Bioorganic Chemistry
Editorial: Multi-target drug discovery: an opportunity for novel and repurposed bioactive compounds
Farmacologia e toxicologia · Frontiers in Pharmacology
Inhibitory effects of thiophene-2-thiazole hybrids against sensitive strains and resistant clinical isolates of Mycobacterium tuberculosis
Medicina · Bioorganic & Medicinal Chemistry Letters
Generative AI-Driven Discovery and Experimental Validation of a Novel EGFR Inhibitor for the Treatment of Pancreatic Cancer
Farmacologia e toxicologia · Scientific Reports
Dual antileishmanial and immunoregulatory activities of synthetic chalcones against Leishmania braziliensis
Medicina · Microbial Pathogenesis

2025 13

2-Aminothiophene Derivatives—New Drug Candidates Against Leishmaniasis: Drug Design, Synthesis, Pharmacomodulation, and Antileishmanial Activity
Medicina · Pharmaceuticals
Host-Mediated Antimicrobial Effects and NLRP3 Inflammasome Modulation by Caulerpin and Its Derivatives in Macrophage Models of Mycobacterial Infections
Medicina · Microorganisms
Evaluation of the Anti-Mycobacterial and Anti-Inflammatory Activities of the New Cardiotonic Steroid γ-Benzylidene Digoxin-15 in Macrophage Models of Infection
Medicina · Microorganisms
Drug design and synthesis of new N-substituted-thienopyridine based on 2-aminothiophene derivatives as antileishmanial agents
Medicina · Bioorganic & Medicinal Chemistry
Preclinical Evaluation of Selene-Ethylenelacticamides in Tuberculosis: Effects Against Active, Dormant, and Resistant Mycobacterium Tuberculosis and In Vitro Toxicity Investigation
Medicina · Microorganisms
Assessment of MepA inhibition potential using thiadiazine derivatives through fluorometry, docking, and qPCR
Medicina · Gene Reports
Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the Staphylococcus aureus 1199B Strain
Medicina · Pharmaceuticals
2-Aminothiophene derivatives reduce resistance to fluoroquinolones in Staphylococcus aureus strains which overexpress NorA and MepA efflux pumps
Medicina · Biochimie
Advances in leishmaniasis therapy: preparation, characterization and in vitro evaluation of poly (lactic acid) polymeric nanoparticles with the drug candidate SB-83
Medicina · Nanotechnology
Potential Inhibitors of SARS-CoV-2 Developed through Machine Learning, Molecular Docking, and MD Simulation
Farmacologia e toxicologia · Medicinal Chemistry
Orofacial antinociceptive effect of a novel 2-amino-thiophene derivative and its possible targets of action
Medicina · Brazilian Oral Research
FERAI, a novel brominated chalcone, induces ultrastructural alterations and apoptosis like-death in Leishmania braziliensis
Medicina · Acta Tropica
In vitro and in vivo efficacy of PI3Kγ inhibitor AS605240 in controlling mycobacterial infections
Medicina · Tuberculosis

2024 14

Potential inhibitors of VEGFR1, VEGFR2, and VEGFR3 developed through Deep Learning for the treatment of Cervical Cancer
Farmacologia e toxicologia · Scientific Reports
Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration
Medicina · Biomedicine & Pharmacotherapy
Nanomolar activity of coumarin-3-thiosemicarbazones targeting Trypanosoma cruzi cruzain and the T. brucei cathepsin L-like protease
Medicina · European Journal of Medicinal Chemistry
A consensus reverse docking approach for identification of a competitive inhibitor of acetyltransferase enhanced intracellular survival protein from Mycobacterium tuberculosis
Farmacologia e toxicologia · Bioorganic & Medicinal Chemistry
Assessment In vitro and In silico of the Activity of Thiadiazines as NorA Efflux Pump Inhibitors
Medicina · Current Microbiology
Evaluating efflux pump inhibition in Staphylococcus aureus 1199B strain using thiadiazine-derived compounds: In vitro and in silico approaches
Medicina · Biochimie
Epigenetic dysregulation in cancers by isocitrate dehydrogenase 2 (IDH2)
Bioquímica, genética e biologia molecular · Advances in protein chemistry and structural biology
In vitro and in silico evaluation of the anti-leishmania activity of synthetic chalcones
Medicina · Natural Product Research
MuDRA‐Based Virtual Screening of Terpenes for Anti‐Leishmania Infantum Activity: In Vitro Validation and Mechanistic Insights from Molecular Docking
Medicina · ChemMedChem
Special Issue “Drug Discovery of Antiprotozoal Agents”
Medicina · Pharmaceuticals
Synergistic antifungal effect of thiophene derivative as an inhibitor of fluconazole-resistant Candida spp. biofilms
Medicina · Brazilian Journal of Microbiology
IBPA a mutual prodrug of ibuprofen and acetaminophen alleviates inflammation, immune dysregulation and fibrosis in preclinical models of systemic sclerosis
Medicina · International Immunopharmacology
The Multitarget Action of Vitamins in the Ischemic Stroke
Enfermagem · Current Topics in Medicinal Chemistry
Spectroscopic exploration of mode of binding of ct DNA and BSA with acridone alkaloids isolated from Zanthoxylum leprieurii (Rutaceae)
Bioquímica, genética e biologia molecular · Natural Product Research

2023 6

Computer-Aided drug design of new 2-amino-thiophene derivatives as anti-leishmanial agents
Farmacologia e toxicologia · European Journal of Medicinal Chemistry
ACW-02 an Acridine Triazolidine Derivative Presents Antileishmanial Activity Mediated by DNA Interaction and Immunomodulation
Medicina · Pharmaceuticals
Antileishmanial activity of 2-amino-thiophene derivative SB-200
Medicina · International Immunopharmacology
Coumarin-based derivatives targeting Trypanosoma cruzi cruzain and Trypanosoma brucei cathepsin L-like proteases
Medicina · New Journal of Chemistry
Selene-Ethylenelacticamides and N-Aryl-Propanamides as Broad-Spectrum Leishmanicidal Agents
Medicina · Pathogens
Virtual Screening of Different Subclasses of Lignans with Anticancer Potential and Based on Genetic Profile
Farmacologia e toxicologia · Molecules

2022 3

Medicinal Chemistry of Inhibitors Targeting Resistant Bacteria
Medicina · Current Topics in Medicinal Chemistry
Synthetic thiophenes induce chromosomal damage and trigger apoptosis in human cancer cell lines
Bioquímica, genética e biologia molecular · European Journal of Medicinal Chemistry Reports
Desenvolvimento de grânulos de alginato para veiculação de derivado tiofênico 5CN06 por gelificação ionotrópica
Farmacologia e toxicologia · Research Society and Development

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