Edeildo Ferreira da Silva‐Júnior

Universidade Federal de Alagoas · AL · 73 publicações em 2022–2026

Computational Drug Discovery MethodsHeterocyclic Compound Synthesis and BioactivitySynthesis and Characterization of Heterocyclic CompoundsMosquito-borne diseases and controlTrypanosoma species research and implications

Principais coautores no Nordeste tamanho = publicações em comum

João Xavier de Araújo‐Júnior Thiago Mendonça de Aquino Igor José dos Santos Nascimento Francisco Jaime Bezerra Mendonça Paulo Fernando da Silva Santos-Júnior Leandro Rocha Silva Emanuelly Karla Araújo Padilha Henrique Douglas Melo Coutinho Johnnatan Duarte de Freitas Ana Carolina Justino de Araújo Clara Andrezza Crisóstomo Bezerra Costa Priscilla Ramos Freitas

Publicações recentes

2026 10

Development of coumarin-3-thiosemicarbazones and coumarin-3-oximes as potent inhibitors of mushroom tyrosinase/tyrosine hydroxylase
Bioquímica, genética e biologia molecular · Bioorganic & Medicinal Chemistry Letters
QSAR-based drug discovery of 2-((4-Imino-3,4-dihydroquinazolin-2-yl)thio-substituted analogs targeting Mycobacterium tuberculosis
Farmacologia e toxicologia · Bioorganic & Medicinal Chemistry
2-Aminothiophene Derivative SB-83 Inhibits Trypanothione Reductase and Modulates Cytokine Production in Trypanosoma cruzi-Infected Cells
Medicina · Pathogens
Putative Antianxiety Property of Oral Enalapril Formulation in Mice: a Preclinical and in silico Study
Medicina · CNS & Neurological Disorders - Drug Targets
Broad-spectrum antiviral activity of benzothiazole-acrylamide hybrids against Zika, Dengue, Chikungunya, and Sindbis viruses
Medicina · Results in Chemistry
Anxiolytic Potential of Selected Essential Oils and Their Impact on Motor Function
Medicina · International Journal of Molecular Sciences
Inhibitory effects of thiophene-2-thiazole hybrids against sensitive strains and resistant clinical isolates of Mycobacterium tuberculosis
Medicina · Bioorganic & Medicinal Chemistry Letters
Aptamers as immunomodulatory therapeutic alternatives targeting neglected tropical diseases (NTDs)
Bioquímica, genética e biologia molecular · Advances in protein chemistry and structural biology
In Vitro and In Silico Evaluation of the Potentiating Effect of Thiadiazine Derivatives Against Multidrug-Resistant (MDR) Bacterial Strains
Medicina · Antibiotics
The substrate envelope strategy: Structural basis for resistance mitigation in antiviral drug design
Farmacologia e toxicologia · Pharmaceutical Science Advances

2025 12

Application of Artificial Intelligence-Based Approaches in the Discovery and Development of Protein Kinase Inhibitors (PKIs) Targeting Anticancer Activity
Farmacologia e toxicologia · Current Topics in Medicinal Chemistry
Characterization of a novel small chemical entity with anxiolytic- and antidepressant-like effects targeting multiple receptors
Medicina · European Journal of Pharmacology
Assessment of MepA inhibition potential using thiadiazine derivatives through fluorometry, docking, and qPCR
Medicina · Gene Reports
Bifenthrin Under Scrutiny: Revisiting Toxicological Evidence Amid Regulatory Gaps
Farmacologia e toxicologia · Journal of Applied Toxicology
Alpha-synuclein aggregation in Parkinson’s disease
Medicina · Advances in protein chemistry and structural biology
Larvicidal activity, oviposition deterrence, enzymatic test and docking of essential oil of Laurencia dendroidea (Rhodophyta, Ceramiales) for control of the mosquito Aedes aegypti L.
Ciências agrárias e biológicas · Algal Research
Evaluation of the Efflux Pump Inhibition Activity of Thiadiazine-Derived Compounds Against the Staphylococcus aureus 1199B Strain
Medicina · Pharmaceuticals
Polo-like Kinase 1 (PLK1) Inhibitors Targeting Anticancer Activity
Bioquímica, genética e biologia molecular · Kinases and Phosphatases
Antidiabetic Activity and Inhibitory Effects of Derivatives of Advanced Aminoguanidine Glycation
Bioquímica, genética e biologia molecular · ACS Omega
Revealing the water-catalyzed activation of Chikungunya virus non-structural protein 2 (nsP2)
Medicina · Journal of Molecular Graphics and Modelling
Exploring therapeutic strategies based on chaperon-mediated disaggregation
Bioquímica, genética e biologia molecular · Advances in protein chemistry and structural biology
New Cinnamamide and Derivatives as New Larvicides against Aedes aegypti Vector Larvae: Facile Synthesis, In Silico Study, In Vitro Noncytotoxicity, and Nontoxicity against Zebrafish
Ciências agrárias e biológicas · ACS Omega

2024 12

Recent advances in the molecular design and applications of viral RNA-targeting antiviral modalities
Bioquímica, genética e biologia molecular · Drug Discovery Today
Cyrene™ as a tyrosinase inhibitor and anti-browning agent
Bioquímica, genética e biologia molecular · Food Chemistry
Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration
Medicina · Biomedicine & Pharmacotherapy
Nanomolar activity of coumarin-3-thiosemicarbazones targeting Trypanosoma cruzi cruzain and the T. brucei cathepsin L-like protease
Medicina · European Journal of Medicinal Chemistry
Oropouche virus – The “Newest” invisible public enemy?
Medicina · Bioorganic & Medicinal Chemistry
A consensus reverse docking approach for identification of a competitive inhibitor of acetyltransferase enhanced intracellular survival protein from Mycobacterium tuberculosis
Farmacologia e toxicologia · Bioorganic & Medicinal Chemistry
Assessment In vitro and In silico of the Activity of Thiadiazines as NorA Efflux Pump Inhibitors
Medicina · Current Microbiology
Evaluating efflux pump inhibition in Staphylococcus aureus 1199B strain using thiadiazine-derived compounds: In vitro and in silico approaches
Medicina · Biochimie
Development of α-acyloxycarboxamides targeting Leishmania amazonensis parasite
Medicina · New Journal of Chemistry
Multi-target Compounds against Trypanosomatid Parasites and Mycobacterium tuberculosis
Medicina · Current Drug Targets
A Promising Frontier: Cannabis's Medicinal Prospects in Alagoas, Brazil
Medicina · Brazilian Journal of Clinical Medicine and Review
LQM467 is a potential antiviral for ZIKV in pregnancy
Medicina · Placenta

2023 16

Emerging drug design strategies in anti-influenza drug discovery
Medicina · Acta Pharmaceutica Sinica B
BACE-1 Inhibitors Targeting Alzheimer's Disease
Neurociência · Current Alzheimer Research
Design, synthesis, antiviral evaluation, and In silico studies of acrylamides targeting nsP2 from Chikungunya virus
Medicina · European Journal of Medicinal Chemistry
Larvicidal activity, enzyme inhibitory effect, and molecular docking by essential oil, hydrolate, aqueous extract, and major compounds from the leaves of Eugenia uniflora against Aedes aegypti
Ciências agrárias e biológicas · Industrial Crops and Products
Computer-aided drug design in seeking viral capsid modulators
Farmacologia e toxicologia · Drug Discovery Today
Coumarin-based derivatives targeting Trypanosoma cruzi cruzain and Trypanosoma brucei cathepsin L-like proteases
Medicina · New Journal of Chemistry
Insights on Microsomal Prostaglandin E2 Synthase 1 (mPGES-1) Inhibitors using Molecular Dynamics and MM/PBSA Calculations
Farmacologia e toxicologia · Letters in Drug Design & Discovery
Natural Compounds as Inhibitors of Aβ Peptide and Tau Aggregation
Neurociência · CNS & Neurological Disorders - Drug Targets
Development of chalcone-like derivatives and their biological and mechanistic investigations as novel influenza nuclear export inhibitors
Medicina · European Journal of Medicinal Chemistry
Insights on Natural Products Against Amyotrophic Lateral Sclerosis (ALS)
Medicina · Current Neuropharmacology
Recent advances in medicinal chemistry of Neglected Tropical Diseases (NTDs)
Imunologia e microbiologia · European Journal of Medicinal Chemistry
Sulfonic Acid: Key Drug Design Elements With potent, broad-ranging Pharmacological Activities
Farmacologia e toxicologia · Future Medicinal Chemistry
Naphthoquinone Derivatives Targeting Melanoma
Farmacologia e toxicologia · Current Topics in Medicinal Chemistry
Preclinical data on morpholine (3,5-di-tertbutyl-4-hydroxyphenyl) methanone induced anxiolysis
Neurociência · Naunyn-Schmiedeberg s Archives of Pharmacology
“You’ve got the Body I’ve got the Brains” – Could the current AI-based tools replace the human ingenuity for designing new drug candidates?
Farmacologia e toxicologia · Bioorganic & Medicinal Chemistry
PI3K Signaling Pathways as a Molecular Target for Glioblastoma Multiforme
Medicina · Current Protein and Peptide Science

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